For men, two enzymes are characteristically released at various stages during the course of sex. These enzymes are called cyclic GMP and PDE-5.
The cyclic GMP is responsible for promoting a free flow of healthy levels of blood towards the penis in order to achieve an erection during sexual arousal. The PDE-5, on the other hand, is responsible for canceling the effects of cyclic GMP after ejaculation so that the penis may return to flaccidity.
However, the PDE-5 enzymes of men with erectile dysfunction (ED) respond prematurely and aggressively against the cyclic GMP during arousal, making it impossible for a man to maintain an erection.
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