If you are consistently struggling with erectile dysfunction (ED), a form of male sexual dysfunction involving difficulty becoming erect or maintaining an erection, there is a range of excellent medications you can take to stimulate healthy erections.
Most people are familiar with Viagra, which was the first effective ED medication to ever hit the market in 1998. It revolutionised the game in terms of sexual dysfunction medication as it was one of the first treatments that worked so effectively for millions of men. Viagra contained the active ingredient sildenafil citrate and was known by many as the “little blue pill” and “vitamin V”.
It was only in 2003 that another PDE-5 inhibitor designed to treat ED was developed. Cialis contained the active ingredient tadalafil 20 mg and was essentially the same as Viagra, differing only in its impressively long-lasting onset of action which remained active for 24-36 hours. This earned Cialis the nickname “the Weekender” pill.
Finally, in 2003 another hugely successful ED medication hit global markets:
Levitra : Levitra contains the active ingredient vardenafil and lasts slightly longer than Viagra at an average of 10 hours whereas Viagra lasts around 6-7 hours. A major benefit of Levitra is that it is associated with relatively fewer side effects than both Cialis and Viagra.
How does Vardenafil Work?
Vardenafil works in exactly the same way as both sildenafil and tadalafil by inhibiting the activity of the enzyme phosphodiesterase type 5 (PDE-5). In men with ED, PDE-5 tends to overproduce which results in the underproduction of another enzyme known as cyclic guanosine monophosphate (cGMP) as PDE-5 is responsible for breaking down cGMP.
cGMP is critical for the production of healthy erections as it stimulates blood flow to the penis once the man becomes sexually aroused. By hindering the activity of PDE-5, vardenafil thus enables cGMP to perform this function without obstruction.
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